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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b3c8551960b226ca3e84d1cdad478dbdc78516da7e5a39f850cd7e594669f86' 
  AND token = 'JPKhTIjb+TIuqPPdM7KcE+yszD1HiUVnRcvt+2Aur5Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}