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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a49157ce4bcc7bd0bb6544a21351ff46b1158df9c0d665d9fef557461194fca' 
  AND token = 'cr7+I3vqW+lfwF//2gupQ5rPPxhc5Ft+85cyLmvK9i0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}