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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'effd1ccac840884874b6c9b85cf9bdac5c862a7ade03387a10883fa647da7215' 
  AND token = '7fh6ZaMsgyznBJaWqPJhVq5zWPDsp8T4IgVNJi+aJq8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}