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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8978af446efa0174f8f3babd453276b1fb8df7027c13e006b4ce591fb8c1beeb' 
  AND token = 'mEtEhOFx2v/Z79ojUIQk8uEDlqHIpiCALi58Ztap+X8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}