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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dda5dfc01558205c42186bdb8ab648b4af5399e1d7c0d3a400f9b0bc0309553' 
  AND token = 'XNGvK7iF8dsMTxF3F1RM/DDo6aZuj/xTaSV0UR/ssNw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}