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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a5d49cc9cc35d8fdd25f00c030fe0448396cff1ae257a87e05d58ba400fb834' 
  AND token = 'ZJ5EdZdnycWyebZEH2P+X+gu5oCGI1Lsd9KI1NdiWXg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}