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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1da1c37aad4680a8b8a01536fd0982f941a50244b0dcdf22e58e4ce81b5b3157' 
  AND token = 'sFZNoMG3Pvb2/AujWJcm7CAUyb3FkjjpTUT1z60RLtY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}