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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a45306b5e5f3080bf5da81cef136777f1d272ab2bf074fc35d7a96614e89d1e5' 
  AND token = 'D/LFkPR5PcyhUovCwM3VD1YKUnMCJ5cyQMpVZWC2PA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}