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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6353ee570800ce1c1a438d78727ca7f3ab6c3165ffb4574e1044ce395120946a' 
  AND token = 'UU0R6w9SOh0bT23ADpuRvqxi3JBNAXEy+9w6CpVUXj4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}