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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6281c8ae2fc5dbebe7cbd200e5b7a480d275dcac97fd3111b2e85b71c2d3f210' 
  AND token = 'WewaIJtnwaHkqGTmAOVkZ0zMWuZK+dFwPFQIdfl8x7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}