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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b54b78ee0944528a0e18938643cb377cf1c13fbdba29e1dfea46ed06b3780232' 
  AND token = 'e9Ebk+9v0wwpkC++qjThD37b+CVjt3XbcUPoGq6BDA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}