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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e14535bb42e495d9023879e32437178a78332be205347a07d97db774d6c78ba4' 
  AND token = 'ru9aa9jA0Gvr8KRMMMWq+FE0HpxBX+miYdRHlyXjXAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}