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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b365438ac7e827c3779e71318c96cbe91056c1c8348019a13ac5433ca9de6e54' 
  AND token = 'tAMWMt1M8GxeYonHvTOkum/Zgz1DWiw4tnjjfKmXRkc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}