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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8e1a8fc47c07edf678c26b2cd88d0ef073af691a63571fb229a4a2de09cd4d5' 
  AND token = 'UOepAHaYs+ncxH5q1mTCzOrHfj+a3A1HQ7oZXsCKik8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}