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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f3e8dfc133643dd989d61ca636c82699dc1fe3b5021590d67a5106cffb680309' 
  AND token = '5D5Du/YTOQstq9+0su5sGWbZV71vPDd0+2F0H3VZJAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}