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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729ab8f1d31162859f5eb8bf8762607c79272529aca88c9a276752ac7a1ccf2d' 
  AND token = 'uE8eDQtTpB1cS3u3R+QMxU2WxgUgfKEKNe8gbhehqyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}